Central nervous system toxicity of cyclosporin A treatment in rheumatoid arthritis.

نویسندگان

  • S Kutlay
  • S Savaş
  • P Yalçin
  • S Ataman
  • S Ergin
چکیده

A 35-yr-old woman with rheumatoid arthritis, receiving cyclosporin A, presented with diplopia, ptosis, loss of horizontal and vertical eye movements, dysarthria, nasal regurgitation. After differential diagnosis, cyclosporin A neurotoxicity was suspected and the treatment stopped. All side-effects were reversed with the discontinuation of the drug. Central nervous system neurotoxicity with low-dose cyclosporin A treatment was discussed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Sulfasalazine plus Chloroquine-Induced Mood Disorder in a Patient with Rheumatoid Arthritis

Rheumatoid arthritis is a chronic systemic inflammatory disease that affects approximately 0.5-1% of the world population. The current approach to this disease is to start an intensive treatment without delay once the disease has developed. Various studies in the literature have shown that combination of disease modifying antirheumatic drugs such as sulfasalazine and chloroquine offers a more a...

متن کامل

O4: Central Nervous System Involvement in Rheumatoid Arthritis: Possible Role of Chronic Inflammation and TNF Blocker Therapy

Rheumatoid arthritis (RA) is a chronic disease, the etiology of which has yet to be clarified, which causes activation of proinflammatory pathways that bring about joint and systemic inflammation. In recent years, the pathophysiology of CNS involvement that can occur in RA has attracted a great deal of attention. Emphasis has focused on the possibility that CNS involvement occurs due to bl...

متن کامل

Liver Toxicity in Rheumatoid Arthritis Patients Treated With Methotrexate

Background:Methotrexate (MTX) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (RA) which can be associated with toxic effects on different organs. This study was designed to investigate the hepatotoxic effects in RA patients treated with MTX. Methods: In this cross-sectional observational study, RA patients who received standard d...

متن کامل

Assessment of efficacy and acceptability of low dose cyclosporin in patients with rheumatoid arthritis.

The efficacy of cyclosporin in a double blind, placebo controlled trial of four months' duration has previously been reported by us. To assess the benefit-to-risk of cyclosporin this study was followed by a one year open trial including 49 of the previous 52 patients. Cyclosporin was given at an initial dosage of 5 mg/kg/day and then modulated on the basis of efficacy and renal toxicity. During...

متن کامل

Molecular Detection of Bacterial Etiology of Rheumatoid Arthritis

Background and purpose: Etiology of rheumatoid arthritis is not fully recognized. The purpose of this study was to use universal and specific primers to trace bacteria in the blood and synovial fluid in patients with rheumatoid arthritis. Materials and methods: In this experimental study, a PCR method was developed to identify a wide range of bacteria in general and Staphylococcus aureus in sp...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British journal of rheumatology

دوره 36 3  شماره 

صفحات  -

تاریخ انتشار 1997